Skin reactions with glucosamine

ADRAC has received 51 reports of allergic skin reactions including erythematous rash, angioedema, urticaria, rash and pruritus with glucosamine. Some glucosamine is obtained from seafood, and products sold in Australia containing glucosamine from this source have a statement specifying this on the label. People with a shellfish allergy may be more susceptible to allergic skin reactions when taking glucosamine sourced from seafood. In several cases reported to ADRAC, the patient had tolerated another glucosamine-containing product without adverse effect.

Reference
Australian Adverse Drug Reactions Bulletin
Volume 24, Number 6, December 2005